細(xì)胞松弛素D 返回列表頁

參考價(jià):2500

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型號(hào)
HY-N6682
品牌
MCE
廠商性質(zhì)
代理商
所在地
杭州市

規(guī)格

1mg 2500元 10000支可售

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CAS號(hào)	22144-77-0	產(chǎn)地	國產(chǎn)
規(guī)格	1mg	級(jí)別	化工級(jí)
證書	ISO系列證書

CAS號(hào)

22144-77-0

產(chǎn)地

國產(chǎn)

規(guī)格

1mg

級(jí)別

化工級(jí)

證書

ISO系列證書

Cytochalasin D (Synonyms: 細(xì)胞松弛素D; Zygosporin A; NSC 209835)

生物活性

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap

體外研究(In Vitro)

Cytochalasin D (3 and 10 μM; 30 min) causes retraction and arborization of COS-7 cells and conversion of F-actin from long fibers to punctate structures^[1].
Cytochalasin D (0.3, 1, 3 and 10 μM; 30 min) concentration-dependently decreases the rate of actin depolymerization in COS-7 cells^[1].
Cytochalasin D (1 μM; NIH3T3 cells) disrupts stress fibers, induces phosphorylation of Yap, while cells maintains original area and lost nuclear Yap localization

Cell Line:	COS-7 cells^[1]
Concentration:	3 and 10 μM
Incubation Time:	30 min
Result:	Caused retraction and arborization of COS-7 cells and conversion of F-actin from long fibers to punctate structures.

分子量：507.62

Formula：C₃₀H₃₇NO₆

CAS 號(hào)：22144-77-0

中文名稱：細(xì)胞松弛素D

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式：

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

DMSO : 25 mg/mL (49.25 mM; ultrasonic and warming and heat to 60°C)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	1.9700 mL	9.8499 mL	19.6998 mL
5 mM	0.3940 mL	1.9700 mL	3.9400 mL
10 mM	0.1970 mL	0.9850 mL	1.9700 mL

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

參考文獻(xiàn)

[1]. Shoji K, et, al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7.

[2]. Flanagan MD, et, al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8.

[3]. Catalano M, et, al. Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2019 Dec 19;9(1):1703244.

[4]. Wada K, et, al. Hippo pathway regulation by cell morphology and stress fibers. Development. 2011 Sep;138(18):3907-14.

注：產(chǎn)品僅用于科研