Methylproamine 返回列表頁(yè)

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型號(hào)
HY-15620
品牌
MCE
廠商性質(zhì)
代理商
所在地
杭州市

規(guī)格

50mg 2400元 10000支可售

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CAS號(hào)	188247-01-0	產(chǎn)地	國(guó)產(chǎn)
規(guī)格	50mg	級(jí)別	化工級(jí)
證書	ISO系列證書

CAS號(hào)

188247-01-0

產(chǎn)地

國(guó)產(chǎn)

規(guī)格

50mg

級(jí)別

化工級(jí)

證書

ISO系列證書

甲基丙胺

Methylproamine 是 DNA結(jié)合的輻射保護(hù)劑，它通過(guò)修復(fù)短暫輻射誘導(dǎo)的 DNA 氧化物種起作用，也可通過(guò)保護(hù) DNA 雙鏈斷裂來(lái)防止電離輻射。

生物活性

Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks^[1].

體外研究(In Vitro)

Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks^[1].

Methylproamine can protect bystander cells from radiation-induced DNA damage^[2].
Methylproamine has a concentration-dependent radioprotective effect^[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:	Keratinocytes
Concentration:	10, 20 μM
Incubation Time:	60 min
Result:	Did not show any detectable cytotoxicity at 10 μM and had appreciable cytotoxicity at 20 μM.

分子量：465.59

Formula：C₂₈H₃₁N₇

CAS 號(hào)：188247-01-0

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

In Vitro:

DMSO : ≥ 41 mg/mL (88.06 mM)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液

1 mM	2.1478 mL	10.7391 mL	21.4781 mL
5 mM	0.4296 mL	2.1478 mL	4.2956 mL
10 mM	0.2148 mL	1.0739 mL	2.1478 mL

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

1.

請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 0.62 mg/mL (1.33 mM); Clear solution
2.

請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 0.62 mg/mL (1.33 mM); Clear solution

參考文獻(xiàn)

[1]. Carl N Sprung, et al. Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. [Content Brief]
[2]. Susanne Burdak-Rothkamm, et al. Radioprotection of targeted and bystander cells by methylproamine. Strahlenther Onkol. 2015 Mar;191(3):248-55. [Content Brief]
[3]. Pavel N Lobachevsky, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [Content Brief]
[4]. Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [Content Brief]
[5]. Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692(1-2):49-52. [Content Brief]
[6]. Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64(3):1067-70. [Content Brief]