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參考價(jià):874

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型號(hào)
HY-17389
品牌
MCE
廠商性質(zhì)
代理商
所在地
杭州市

規(guī)格

50mg 874元 10000支可售

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CAS號(hào)	6902-77-8	產(chǎn)地	國產(chǎn)
規(guī)格	50mg	級(jí)別	化工級(jí)
證書	ISO系列證書

CAS號(hào)

6902-77-8

產(chǎn)地

國產(chǎn)

規(guī)格

50mg

級(jí)別

化工級(jí)

證書

ISO系列證書

Genipin (Synonyms: 京尼平; (+)-Genipin)

Genipin ((+)-Genipin) 是衍生自 Gardenia jasminoides Ellis 果實(shí)的天然交聯(lián)劑。Genipin 抑制細(xì)胞中的 UCP2 (解偶聯(lián)蛋白 2)。Genipin 具有多種生物活性，包括蛋白質(zhì)調(diào)節(jié)，免疫抑制，抗血栓形成和對(duì)海馬神經(jīng)元的保護(hù)。Genipin 也可用于 2 型糖尿病研究。

生物活性

Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research^[1]^[2].

體外研究(In Vitro)

Genipin increases mitochondrial membrane potential, increased ATP levels, closed KATP channels, and stimulated insulin secretion in pancreatic islet cells. Genipin causes suppression of insulin signal transduction through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate-1 (IRS-1), thus impairing insulin-stimulated glucose uptake in 3T3-L1 adipocytes^[1].
Genipin activates IRS-1, PI3-K, and downstream signaling pathway and increases concentrations of calcium, resulting in glucose transporter 4 (GLUT4) translocation and glucose uptake increase in C2C12 myotubes^[1].
Cytochrome c content increases significantly in the cytosol of Genipin-treated FaO cells. Activation of caspase-3 and caspase-7 is ultimately responsible for Genipin-induced apoptotic process in hepatoma cells. ROS level notably increases in Hep3B cells treated with 200 μM Genipin^[2].

分子量：226.23

性狀：Solid

Formula：C₁₁H₁₄O₅

CAS 號(hào)：6902-77-8

中文名稱：京尼平

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)

In Vitro:

DMSO : ≥ 100 mg/mL (442.03 mM)

H₂O : 4 mg/mL (17.68 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	4.4203 mL	22.1014 mL	44.2028 mL
5 mM	0.8841 mL	4.4203 mL	8.8406 mL
10 mM	0.4420 mL	2.2101 mL	4.4203 mL

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

1.

請(qǐng)依序添加每種溶劑： PBS
Solubility: 9.09 mg/mL (40.18 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
2.

請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution
3.

請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution
4.

請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

參考文獻(xiàn)

[1]. Ma C, et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20. [Content Brief]
[2]. Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70(9):1398-407.
[3]. Ye D, et al. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. 2018 Mar 9:1-22. [Content Brief]

注：產(chǎn)品僅用于科研