Progesterone (Synonyms: 孕酮; Pregn-4-ene-3,20-dione)
Progesterone是一種類固醇激素,可調(diào)節(jié)月經(jīng)周期,對(duì)懷孕很重要。
生物活性
Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
IC50 & Target
Human Endogenous Metabolite
體內(nèi)研究(In Vivo)
Progesterone (Injections; 1 mg; three consecutive daily) stimulates vessel maturation in the mouse endometrium
Animal Model: | Adult female mice (7-13 wk, 18-28 g)[4] |
Dosage: | 1 mg |
Administration: | Injections; three consecutive daily |
Result: | Stimulated vessel maturation in the mouse endometrium. |
分子量:314.46
Formula:C21H30O2
CAS 號(hào):57-83-0
中文名稱:孕酮
運(yùn)輸條件:Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
溶解性數(shù)據(jù)
DMSO : 25 mg/mL (79.50 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (insoluble)
濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.1801 mL | 15.9003 mL | 31.8005 mL |
5 mM | 0.6360 mL | 3.1801 mL | 6.3601 mL |
10 mM | 0.3180 mL | 1.5900 mL | 3.1801 mL |
請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí),請(qǐng)?jiān)?6 個(gè)月內(nèi)使用,-20°C 儲(chǔ)存時(shí),請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。
以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑:
——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比;如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過加熱和/或超聲的方式助溶
- 1.
請(qǐng)依序添加每種溶劑: 50% PEG300 50% saline
Solubility: 20 mg/mL (63.60 mM); Suspended solution; Need ultrasonic
- 2.
請(qǐng)依序添加每種溶劑: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution
- 3.
請(qǐng)依序添加每種溶劑: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution
- 4.
請(qǐng)依序添加每種溶劑: 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution
參考文獻(xiàn)
[1]. Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2003 Dec 10;46 Suppl 1:S7-S16.
[2]. Zava DT, et al. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998 Mar;217(3):369-78.
[3]. Komesaroff PA, et al. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001 Jun;4(2):144-50.
[4]. Girling JE, et al. Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology. 2007 Nov;148(11):5433-41. Epub 2007 Aug 9.
注:產(chǎn)品僅用于科研